Daniela Braconi Selected Research

Ochronosis

3/2024	Alkaptonuria.
1/2020	Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria.
1/2020	Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial.
1/2019	Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria.
7/2017	Cytoskeleton Aberrations in Alkaptonuric Chondrocytes.
1/2014	Amyloidosis, inflammation, and oxidative stress in the heart of an alkaptonuric patient.
9/2013	Antioxidants inhibit SAA formation and pro-inflammatory cytokine release in a human cell model of alkaptonuria.
9/2012	Biochemical and proteomic characterization of alkaptonuric chondrocytes.
12/2011	Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis.
11/2010	Proteomic and redox-proteomic evaluation of homogentisic acid and ascorbic acid effects on human articular chondrocytes.

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Daniela Braconi Research Topics

Disease

31	Alkaptonuria 03/2024 - 10/2010
11	Ochronosis 03/2024 - 10/2010
10	Amyloidosis 12/2020 - 01/2011
6	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 10/2010
5	Inflammation (Inflammations) 11/2022 - 12/2016
3	Disease Progression 01/2020 - 12/2016
2	Rare Diseases (Rare Disease) 01/2021 - 11/2012
2	Tyrosinemias (Tyrosinemia) 01/2017 - 04/2016
2	Rheumatic Diseases (Rheumatism) 12/2016 - 11/2016
2	Metabolic Diseases (Metabolic Disease) 04/2016 - 11/2015
2	Heart Failure 01/2012 - 01/2011
2	Alkaptonuric ochronosis 12/2011 - 10/2010
2	Infections 04/2009 - 10/2007
1	Knee Injuries (Knee Injury) 12/2020
1	Osteoarthritis 12/2020
1	Wounds and Injuries (Trauma) 11/2016
1	Rheumatoid Arthritis 01/2014
1	Amyloid Plaque 01/2014
1	Parkinson Disease (Parkinson's Disease) 11/2012
1	Neoplasms (Cancer) 02/2012

Drug/Important Bio-Agent (IBA)

20	Homogentisic AcidIBA 03/2024 - 10/2010
18	Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)IBA 03/2024 - 10/2010
7	Melanins (Melanin)IBA 01/2019 - 10/2010
6	Serum Amyloid A Protein (Serum Amyloid A)IBA 12/2020 - 09/2013
5	nitisinone (Orfadin)FDA Link 11/2022 - 02/2016
5	EnzymesIBA 01/2022 - 12/2011
5	Amyloid (Amyloid Fibrils)IBA 02/2017 - 01/2011
4	Proteins (Proteins, Gene)FDA Link 12/2020 - 02/2012
4	Tyrosine (L-Tyrosine)FDA Link 12/2016 - 12/2011
3	Biomarkers (Surrogate Marker)IBA 12/2020 - 12/2011
3	Phenylalanine (L-Phenylalanine)FDA Link 12/2016 - 12/2011
3	AntioxidantsIBA 09/2013 - 10/2010
2	Congo RedIBA 01/2014 - 11/2012
2	CytokinesIBA 01/2014 - 09/2013
2	Atrial Natriuretic Factor (ANF)IBA 01/2012 - 01/2011
2	VaccinesIBA 04/2009 - 10/2007
1	CollagenIBA 03/2024
1	chitotriosidaseIBA 12/2020
1	Advanced Oxidation Protein Products (AOPP)IBA 12/2020
1	PolymersIBA 01/2019
1	Acetic Acid (Vinegar)FDA LinkGeneric 07/2017
1	quinone (benzoquinone)IBA 07/2017
1	ProteomeIBA 12/2016
1	Eosine Yellowish-(YS) (Eosin)IBA 11/2016
1	Hematoxylin (Haematoxylon)IBA 11/2016
1	HerbicidesIBA 04/2016
1	DioxygenasesIBA 04/2016
1	LipidsIBA 01/2014
1	AA amyloidosisIBA 11/2012
1	Methotrexate (Mexate)FDA LinkGeneric 11/2012
1	Sulfhydryl Compounds (Thiols)IBA 12/2011
1	AntigensIBA 10/2007

Therapy/Procedure

2	Therapeutics 09/2013 - 11/2012
1	Precision Medicine 01/2021
1	Replacement Arthroplasty 11/2016